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 Som jag kommer ihåg det från bokens slut, höll Hannibal Clarice mer eller mindre kontinuerligt drugged och de lever lyckligt någonsin. 
 Skillnaden är täckt i  AboutFilms  -teckning på slutet, i 12 stycken och en sammanfattning av bokens slut. Ett utdrag: 
  Admittedly, I haven't read it, but the
  novel's ending sounds just awful to me.
  And yet, it still sounds better than the
  movie's ending. At least the novel's
  ending explores the psyche of both
  characters. At least Starling asserts some power, as preposterous as her
  therapeutic techniques may sound.
 Kan det vara att de bara inte har tid att ge boken slut på den fullständiga behandlingen som det förtjänade att bli fullständigt utforskad? Hannibal flyr in i solnedgången är säkert lättare och snabbare än att arbeta igenom och lösa sina psykologiska problem som nämns i synopsisen. 
 Det slutsatsen: 
  In the movie, Hannibal is Starling's self-
  appointed protector and is the same
  person from beginning to end. But he's
  not the same person he was in The
   Silence of the Lambs, nor is he the same
  person Harris portrays in his novel, in which Hannibal is not so much trying to
   protect Starling as he is trying to get her
   in his clutches. In the novel, as ludicrous 
  as it may sound, we have a
   transformation and a resolution. That's
   something we have a right to expect at the end of a trilogy. However, in the
   movie, Hannibal just flies off into the 
  sunset. He is still an enigma. We're just
   set up for another sequel, and perhaps
   another. Don't look now, but Hannibal IX: The Resurrection is just around the corner.
 En inlägg av Lectermate på  Hannibal Lecter Studiolo  säger: 
  In an interview, Ridley Scott said about the end of the book that it was too fast, that it should have been another book before we saw Hannibal and Clarice together.
  
  Scott thinks that Hannibal is in love with Clarice but she rather feels some kind of respect for him, that's why he decided to do another end for his film.
 Till vilken Clariz svarade: 
  That is what he said in the interview, but in real life, there was a big ado, between TH [Thomas Harris, author], Dino/Martha [De Laurentiis/Schumacher, producers] and [director Ridley] Scott, whereupon TH didn't want to agree to the modified ending. 
  
  After they were locked for 5 days engaged in the argument. TH gave in, not without a feeling of disappointment. 
  
  What it odd here, is that the book was written with the foreknowledge that it will turn into a movie. When it was finished up and up until the production of the movie began it seemed clear that the book ending would prevail. Dino and Martha had approved it.
  
  It always seemed as if they modified the ending to the movie with the idea of a sequel. Scott definitely had a sequel in mind. One wonders if he actually READ the book or just an abridgment.
  
  There is no substantiation that might lead even remotely to believe that TH wrote the ending of the book to satisfy any fans. That would be soooooooo unlike TH...