Enterprise-D förstördes 2371 i en konfrontation med Lursa och B'etor i filmen Star Trek Generations .
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Majoritetenavbesättningen(meddeanmärkningsvärdaundantagenfrånCommanderWorf)överfördessedantilldennya"Sovereign-Class" Enterprise-E efter en kort period av strandlov:
"My working assumption was that the Enterprise-E had her keel laid sometime during TNG's last season and was probably going to be given another name. When the Enterprise-D was destroyed, that Sovereign-class ship was nearing completion and was then christened Enterprise."
Ronald D. Moore